Risks and Benefits of Acetaminophen: Especially in Chronic Pain Management
August 19th, 2010Earlier this year I posted this on our News and Research Page; but due to running into several cases the last few weeks regarding people significantly overusing acetaminophen I decided to re-post it on my blog today. Many people undergoing chronic pain management and on several different medications, including those purchase over the counter, may not realize how much acetaminophen they are really taking. Please share this information.
As a starting point I want to reiterate that my premise is that there is no such thing as a “bad” medication; how it’s used and who uses it determines positive or negative outcomes. To most people, acetaminophen is something of a ubiquitous mystery appearing in many combination cough and cold products as well as many prescription pain medications (such as Vicodin and Percocet). Since many different medications contain this ingredient many consumers may not realize they are taking multiple products that contain acetaminophen, an error that can cause significant liver damage in a very short time.
The maximum daily dosage of acetaminophen historically has been 4,000 mg, and it can cause dangerous side effects if people take it in excessive dosages or they have liver disease or drink large amounts of alcohol. This maximum dose recommendation was recommended to be revised in June of 2009 by the FDA advisory panel who voted 21-16 to lower the maximum daily dose of nonprescription acetaminophen, which is currently 4 grams(4,000 mg) - equal to eight pills of a drug such as Extra Strength Tylenol.
In addition the panel voted 24-13 to limit the maximum single dose of acetaminophen to 650 milligrams. The current single dose of Extra Strength Tylenol, for instance, is 1,000 milligrams. The panel also voted 26-11 to make the 1,000-milligram dose of acetaminophen available only by prescription. It should be noted that the FDA is not required to accept the panel’s recommendations, but it typically does so.
Due to these and other concerns John Hopkins Medical center recommends that even though acetaminophen is the drug with the lowest overall risk of side effects, if someone uses acetaminophen regularly, they should see their doctor periodically to be monitored for adverse effects.
However, there are many legitimate benefits for using acetaminophen. For example, a 2004 study that was presented at the 9th World Congress of the Osteoarthritis Research Society International (OARSI) in Chicago showed that the over-the- counter pain reliever acetaminophen, when used as directed, is a safe and effective treatment option for patients suffering from the pain of osteoarthritis of the hip or knee.
According to the results of this study, acetaminophen was found comparable in safety to placebo. There were no statistically significant differences in the number of serious or non-serious adverse events between patients treated with either dose of acetaminophen and placebo. The results of this study confirm that when used as directed, acetaminophen is an effective and safe choice for patients with osteoarthritis and reinforce the American College of Rheumatology guidelines that recommend acetaminophen as a first line therapy to relieve osteoarthritis pain.
Along with its other benefits, acetaminophen is less likely to interact with other medications or irritate the stomach. It is also considered safe for patients with conditions such as heart disease and diabetes.
Below is information from the manufacturer of Tylenol® (active ingredient acetaminophen) that they posted on their website for people who want—or need—to take it, so they can do so responsibly and safely.
Importantly, you can confidently continue to take TYLENOL® according to the directions currently on the package and can prevent inappropriate use by:
Reading the label before each use and always following the directions
Never taking more than the recommended dose
Never using two products containing acetaminophen at the same time
Keeping medicine out of the reach of children
Consulting a healthcare professional with questions
The safety and efficacy of acetaminophen has been established through more than 50 years of clinical use and scientific investigation and it is safe when used as directed.
Any decisions about taking medications should be made with the advice and consultation of an appropriate healthcare provider. I believe that learning as much as possible and educating our patients is one of the most important components of an effective chronic pain management plan.
To learn more about effective medication and chronic pain management please check out my article 12 Personal Action Steps for Chronic Pain and Medication Management that you can download for free on our Article page.
If you’d like to receive training for helping people with relapse prevention, I’m very excited to announce that the Gorski-CENAPS Corporation is presenting The Relapse Prevention Therapy44 Hour Certification Training in Ft. Lauderdale October 18-22, 2010. To learn more about this 5 day 44 hour training you can check out our Calendar page.

You can learn about the Addiction-Free Pain Management® System at our website www.addiction-free.com. If you are working with people undergoing chronic pain management and want to learn how to develop a plan for managing their chronic pain and coexisting psychological disorders; including depression, addiction and other coexisting psychological disorders effectively; please consider my book Managing Pain and Coexisting Disorders: Using the Addiction-Free Pain Management® System. To purchase this book please Click Here.
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